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Institute of Medical Virology


Journal Club Medical Virology 2023

Journal Club Medical Virology 2022

Spring Semester 2020

Autumn semester 2019


Summer holidays  


Summer holidays  


Davide Eletto (Group BGH)

Anthony Petkidis (Group UG)

HDAC stimulates gene expression through BRD4 availability in response to IFN and in interferonopathies

Picornavirus RNA Recombination Counteracts Error Catastrophe


Nora Schmidt (group BGH)

Romain Volle (group UG)

Regulation of HIV-1 Gag-Pol Expression by Shiftless, an Inhibitor of Programmed -1 Ribosomal Frameshifting

Slow infection due 1 to lowering amount of intact versus empty particles is a characteristic feature of Coxsackievirus B5, dictated by the structural proteins


Magdalena Schwarzmüller (group AT)

Mila Sempere Borau (group SSt)

Lack of therapeutic efficacy of anantibody to a4b7 in SIVmac251-infected rhesus macaques

m6A modification controls the innate immuneresponse to infection by targeting type I interferons


Anouk Lkharazzi (group BGH)

Gómez González Alfonso (group UG)

An alternatively transcribed TAZ variant negatively regulates JAK-STAT

HIV Infection Stabilizes Macrophage-T Cell Interactions To Promote Cell-Cell HIV Spread


Nina Mair (group BGH)

Caio Foulkes (Group AT)

Influenza virus uses transportin 1 for vRNP debundling during cell entry

The viral protein corona directs viral pathogenesis and amyloid aggregation


No Journal Club



Samira Schiefer (group BGH)

Elena Fritz (group SSt)

Mitochondria-localised ZNFX1 functions as adsRNA sensor to initiate antiviral responses through MAVS

Zika Virus NS3 Mimics a Cellular 14-3-3-BindingMotif to Antagonize RIG-I- and MDA5-MediatedInnate Immunity


No Journal Club  
23.12.2019 Christmas Break, No Journal Club  

Marie Pohl (group SSt)

Characterization of orally efficacious influenza drug with high resistance barrier in ferrets and human airway epithelia


Michael Bauer (Group UG)

Sonja Harms (group BGH)

Cyclophilin A protects HIV-1 from restriction by human TRIM5α

Genome-wide CRISPR screen identifies host dependency factors for influenza A virus infection


Spring semester 2019


Davide Eletto (Group BGH)

Luca Murer (group UG)

Life-threatening influenza pneumonitis in a child with inherited IRF9 deficiency


Matteo Bianchi (group AT)

Daniele Sequeira (group UG)

Pseudovirus rVSVDG-ZEBOV-GP Infects Neurons in Retina and CNS, Causing Apoptosis and Neurodegeneration in Neonatal Mice

Late activation of the Raf/MEK/ERK pathway is required for translocation of the respiratory syncytial virus F protein to the plasma membrane and efficient viral replication


Nora Schmidt (group BGH)

Merle Schanz (group AT)

Regulation of HIV-1 Gag-Pol Expression by Shiftless, an Inhibitor of Programmed -1 Ribosomal Frameshifting

Evolution of the Envelope Glycoprotein of HIV-1 Clade B towards Higher Infectious2 Properties over the Course of the Epidemic


Annika Hunziker (group SST)

Sonja Harms (group BGH)

Comparative Flavivirus-Host Protein Interaction Mapping Reveals Mechanisms of Dengue and Zika Virus Pathogenesis

Spatiotemporal control of interferon-induced JAK/STAT signalling and gene transcription by the retromer complex


Friedrich Nikolas (group AT)

Umut Karakus (group SST)

Innate immune recognition of glycans targets HIV nanoparticle immunogens to germinal centers

Influenza binds phosphorylated glycans from human lung


Idoia Busnadiego (group BGH)

Harini Subbaraman (group AT)

Methyltransferase SETD2-Mediated Methylation ofSTAT1 Is Critical for Interferon Antiviral Activity

The repertoire of maternal anti-viral antibodiesin human newborns


Eva Spieler (group SST/BGH)

Anthony Petkidis (Group UG)

ADP-ribosyltransferase PARP11 modulates the interferon antiviral response by mono-ADPribosylating the ubiquitin E3 ligase β-TrCP

Chloroviruses lure hosts through long-distance chemical signaling


Matthias Glögl (group AT)

Fanny Georgi (group UG)

Complement C4 Prevents Viral Infection through Capsid Inactivation

A multicellular way of life for a multipartite virus


Liridona Maliqui (group AT)

Jacob Börold (group BGH)

Immunization with Components of the Viral Fusion Apparatus Elicits Antibodies That Neutralize Epstein-Barr Virus in B Cells and Epithelial Cells

Viral and metazoan poxins are cGAMP-specific nucleases that restrict cGAS–STING signalling


Pfingstmontag, NO Journal Club  


Olszewski Dominik (group UG)

Verena Kufner (group AT)

Adenovirus 5 E1A Interacts with E4orf3 To Regulate Viral Chromatin Organization

Clinical Metagenomic Sequencing for Diagnosis of Meningitis and Encephalitis


No Journal Club



Sira Günther (group SSt)

Romain Volle (group UG)

Influenza Virus Exploits an Interferon-Independent lncRNA to Preserve Viral RNA Synthesis through Stabilizing Viral RNA Polymerase PB1

Polyamine Depletion Inhibits Bunyavirus Infection via Generation of Noninfectious Interfering Virions

Autumn Semester 2018

06.08.18 Summer holidays  
20.08.18 Summer holidays  

Anthony Petkidis (Group UG)

Sonja Harms (group BGH)

Nanoscale Polarization of the Vaccinia Virus Entry Fusion Complex Drives Efficient Fusion

Nuclear-resident RIG-I senses viral replication inducing antiviral immunity


Fanny Georgi (group UG)

Liridona Maliqui (group AT)

The mobility of packaged phage genome controls ejection dynamics

Interdomain Stabilization Impairs CD4 Binding and Improves Immunogenicity of the HIV-1 Envelope Trimer


Jacob Börold (group BGH)

Olszewski Dominik (group UG)

A CRISPR screen identifies IFI6 as an ER-resident interferon effector that blocks flavivirus replication

Viral unmasking of cellular 5S rRNA pseudogene transcripts induces RIG-I-mediated immunity


Verena Kufner (group AT)

Marie-Theres Pohl (group SSt)

Field-deployable viral diagnostics using CRISPR-Cas13

Regional Differences in Airway Epithelial Cells Reveal Tradeoff between Defense against Oxidative Stress and Defense against Rhinovirus


Janine Vetter (group SSt)

Differentiated human airway organoids to assess infectivity of emerging influenza virus


Martinez Lopez Itzel (group UG)

Universal protection against influenza infection by a multidomain antibody to influenza hemagglutinin


NO Journal Club


Sira Günther (group SSt)

Romain Volle (group UG)

The interferon-inducible isoform of NCOA7 inhibits endosome-mediated viral entry

An upstream protein-coding region in enteroviruses modulates virus infection in gut epithelial cells

24.12.18 Christmas Eve, NO Journal Club  

Gómez González Alfonso (group UG)

NP220 mediates silencing of unintegrated retroviral DNA



Caio Foulkes (group AT)

Naoures Khabthani (group SH)

A majority of HIV persistence during antiretroviral therapy is due to infected cell proliferation

Interferon-induced Transmembrane Protein  restricts replication of  virus that enter cells via the plasma membrane


Spring Semester 2018


Davide Eletto (Group BGH)

Michel Crameri (group JP)

Severe viral respiratory infections in children with IFIH1 loss-of-function mutations

TRIM29 promotes DNA virus infections by inhibiting innate immune response


Elizaveta Elshina (Group SSt)

Chris Brunner (group AT)

Influenza A Virus Negative Strand RNA is Translated for CD8+ T Cell Immunosurveillance

Hepatitis E virus ORF3 is a functional ion channel required for release of infectious particles

05.03.18 Nora Schmidt (group BGH) Intrinsic Immunity Shapes Viral Resistance of Stem Cells

Prasad Vibhu (Group UG)

Matthias Glögl (group AT)

Inflammasome activation triggers caspase-1-mediated cleavage of cGAS to regulate responses to DNA virus infection

An interferon-independent lncRNA promotes viral replication by modulating cellular metabolism

02.04.18 Easter Monday, NO Journal Club  
16.04.18 Sechseläuten, NO Journal Club  

Domingues Patricia (group BGH)

Tania Jetzer (Group SH)

Genome-wide CRISPR/Cas9 Screen Identifies Host Factors Essential for Influenza Virus Replication

Zika virus has oncolytic activity against glioblastomastem cells


Friedrich Nikolas (group AT)

Eva Spieler (group SST/BGH)

Evolution of a designed protein assembly encapsulating its own RNA genome

Demethylase JMJD6 as a New Regulator of Interferon Signaling:Effects of HCV and Ethanol Metabolism


Annika Hunziker (group SSt)

Michael Bauer (Group UG)

A Sialylated Voltage-Dependent Ca2+ Channel Binds Hemagglutinin and Mediates Influenza A Virus Entry into Mammalian Cells

Single HIV-1 Imaging Reveals Progression of Infection through CA-Dependent Steps of Docking at the Nuclear Pore, Uncoating, and Nuclear Transport


Umut Karakus (group SST)

Idoia Busnadiego (group BGH)

Nuclear TRIM25 Specifically Targets Influenza Virus Ribonucleoproteins to Block the Onset of RNA Chain Elongation

Cyclin-dependent kinase activity is required for type I interferon production


Claus Kadelka (group AT)

Luca Murer (group UG)

Fitness landscape of the human immunodeficiency virus envelope protein that is targeted by antibodies

Protein composition of the hepatitis A  virus quasi-envelope


Hannah Turkington (group BGH)

Harini Subbaraman (group AT)

PARP12 suppresses Zika virus infection through PARP-dependent degradation of NS1 and NS3 viral proteins

SUMO2 and SUMO3 redundantly prevent a noncanonical type I interferon response


Robert Witte (group UG)

Communication between viruses guides lysis–lysogeny decisions

Autumn Semester 2017

07.08.17 Summer holidays  
21.08.17 Summer holidays  
04.09.17 Idoia Busnadiego (group BGH) Hepatitis E virus persists in the presence of a type III interferon response
  Claus Kadelka (group AT) Comprehensive Mapping of HIV-1 Escape from a Broadly Neutralizing Antibody
18.09.17 Luca Murer (group UG) PLA2G16 represents a switch between entry and clearance of Picornaviridae
  Harini Subbaraman (group AT) The Evolutionary Pathway to Virulence of an RNA Virus
02.10.17 Hannah Turkington (group BGH) Reovirus inhibits interferonproduction by sequestering IRF3into viral factories
  Fanny Georgi (group UG) Trispecific broadly neutralizing HIV antibodies mediate potent SHIV protection in macaques
16.10.17 Robert Witte (group UG)/ Environmental Stress Causes Lethal Neuro-Trauma during Asymptomatic Viral Infections
  Balthasar Müller (group SH) Glucose Metabolism and Oxygen Availability Govern Reactivation of the Latent Human Retrovirus HTLV-1
30.10.17 Verena Kufner (group AT) The eukaryotic gut virome in hematopoietic stem celltransplantation: new clues in enteric graft-versus-hostdisease
13.11.17 Jacob Börold (group BGH) Diverse Viruses Require the Calcium Transporter SPCA1 for Maturation and Spread
  Sira Günther (group SSt) Nuclear TRIM25 Specifically Targets Influenza Virus Ribonucleoproteins to Block the Onset of RNA Chain Elongation
27.11.17 Emilio Yangüez (group SSt) Sensing Self and Foreign Circular RNAs by IntronIdentity
  Liridona Maliqi (group AT) Broadly protective murine monoclonal antibodies against influenza B virus target highly conserved neuraminidase epitopes
11.12.17 No Journal Club  
25.12.17 Christmas holidays  
08.01.18 No Journal Club  

Caio Foulkes (Group AT)

Fiona Steiner (Group JP)

Antibody-dependent enhancement of severe dengue disease in humans

A Global Interactome Map of the Dengue Virus NS1 Identifies Virus Restriction and Dependency Host Factors

Spring Semester 2017

20.02.17 NO Journal Club: Inauguration Lecture Ben Hale  
06.03.17 Ebner Hanna (group AT) Modified mRNA Vaccines Protect against Zika VirusInfection
20.03.17 Branislav Ivan (group AT) Sequential activation of the three protomers in the Moloney murine leukemia virus Env
  Manuela Bieri (group SH) Herpes Simplex Virus 1 Abrogates the cGAS/STING-Mediated Cytosolic DNASensing Pathway via Its Virion Host Shutoff Protein, UL41
03.04.17 Schanz Merle (group AT) Complete mapping of viral escape from neutralizing antibodies
  Vardan Andriasyan (group UG) VirusMapper: open-source nanoscale mapping of viral architecture through super-resolution microscopy
17.04.17 Easter Monday, NO Journal Club  
01.05.17 Labour Day, NO Journal Club  
15.05.17 Domingues Patricia (group BGH) The RNA Exosome Syncs IAV-RNAPII Transcription to Promote Viral Ribogenesis and Infectivity
  Michel Crameri (group JP) The ubiquitin E3 ligase TRIM31 promotes aggregation and activation of the signaling adaptor MAVS through Lys63-linked polyubiquitination
29.05.17 Caroline Lanz (group SST) Delineating morbillivirus entry, dissemination and airborne transmission by studying in vivo competition of multicolor canine distemper viruses in ferrets
  Antonio Lopez (group BGH) Mutation of the N-Terminal Region of Chikungunya Virus Capsid Protein: Implications for Vaccine Design
12.06.17 Jacobo Sarabia del Castillo Zika Virus Persistence in the Central Nervous System and Lymph Nodes of Rhesus Monkeys
  Eva Müller (group SST/BGH) Evolutionary enhancement of Zika virus infectivity in Aedes aegypti mosquitoes
26.06.17 Annika Hunziker (group SSt) Noumeavirus replication relies on a transient remote control of the host nucleus
10.07.17 Fiona Steiner (group JP) Exploiting the kinesin-1 molecular motor to generate a virus membrane penetration site
  Nikolas Friedrich (group AT) Retroviral host range extension is coupled with Env-activating mutations resulting in receptor-independent entry
24.07.17 Umut Karakus (group SST) Antibodies from a Human Survivor Define Sites of Vulnerability for Broad Protection against Ebolaviruses
  Michael Bauer (group UG) Fusion Stage of HIV-1 Entry Depends on Virus-Induced Cell Surface Exposure of Phosphatidylserine

Autumn semester 2016

Date Speaker Paper Title
22.08.2016 Annika Hunziker (group SSt)

Human papillomavirus promotes Epstein-Barr virus maintenance and lytic reactivation in immortalized oral keratinocytes

05.09.2016 Caroline Lanz (groupSST) Cell autonomous regulation of herpes andinfluenza virus infection by the circadian clock
  Nikos Tsolakos (group BGH) A core viral protein binds host nucleosomes tosequester immune danger signals
19.09.2016 Fiona Steiner (group JP) The Dengue Virus NS5 Protein Intrudes in the
Cellular Spliceosome and Modulates Splicing
  Luca Murer (group UG) Cadherin-related family member 3, a childhood asthmasusceptibility gene product, mediates rhinovirus Cbinding and replication
03.10.2016 Antonio Lopez (group BGH) Mammalian Innate Immune Response to a Leishmania-Resident RNA Virus Increases Macrophage Survival to Promote Parasite Persistence
  Michael Bauer (group UG) Latency Entry of Herpes Simplex Virus 1 Is Determined by the Interaction of Its Genome with the Nuclear Environment
17.10.2016 Corinna Patzina (group BGH) STING Requires the Adaptor TRIF to Trigger Innate Immune Responses to Microbial Infection
  Matthias Glögl (group AT) Genetic dissection of Flaviviridae host factors through genome-scale CRISPR screens
31.10.2016 Vardan Andriasyan (group UG) Remodeling nuclear architecture allows efficient transport of herpesvirus capsids by diffusion
  Harini Subbaraman (group AT) Interferon-driven deletion of antiviral B cells at the onset of chronic infection
14.11.2016 Hannah Turkington (group BGH) Rabies Virus Infection Induces the Formation of Stress Granules Closely Connected to the Viral Factories
  Fanny Georgi (group UG) Zika Virus Depletes Neural Progenitors in Human Cerebral Organoids through Activation of the Innate Immune Receptor TLR3
28.11..2016 Iketani Sho (group UG) Fungal DNA virus infects a mycophagous insect and utilizes it as a transmission vector
  Umut Karakus (group SST) A Herpesvirus Protein Selectively Inhibits Cellular mRNA Nuclear Export
12.12.2016 Robert Witte (group UG) RNA Recombination Enhances Adaptability and Is Required for Virus Spread and Virulence
  Raphael Walker (group JP) HPV31 utilizes the ATR-Chk1 pathway to maintain elevated RRM2 levels and a replication-competent environment in differentiating Keratinocytes
26.12.2016 Christmas holidays  
09.01.2017 Nora Schmidt (group BGH)

The mTOR Complex Controls HIV Latency

  Kannan Abilash (group UG)

miR-124 attenuates Japanese encephalitis virus replication by targeting DNM2

23.01.2017 Liechti Thomas (group AT) Antibody Effector Functions Mediated by Fcg-Receptors Are Compromised during Persistent Viral Infection
  Matthias Glögl (group AT) Sensing of HSV-1 by the cGAS–STING pathway in microglia orchestrates antiviral defence in the CNS
06.02.2017 Nikos Tsolakos (group BGH) A G1-like state allows HIV-1 to bypass SAMHD1 restriction in macrophages
  Prasad Vibhu (group UG) A Single Legionella Effector Catalyzes a Multistep Ubiquitination Pathway to Rearrange Tubular Endoplasmic Reticulum for Replication

Spring semester 2016

Date Speaker Paper Title
11.01.2016 Nikos Tsolakos (group BGH) Neuronal Stress Pathway Mediating a Histone Methyl/Phospho Switch Is Required for Herpes Simplex Virus Reactivation
  Michaela Beer (group UG) The missing link in EBV immune evasion: the BDLF3 gene induces ubiquitination and downregulation of MHC class I and MHC class II
25.01.2016 Alina Rudnicka (group YY) Dengue Virus RNA Structure Specialization Facilitates Host Adaptation
  Claus Kadelka (group AT) Comprehensive Antigenic Map of a Cleaved Soluble HIV-1 Envelope Trimer
Nora Schmidt (group BGH) Neuronal Stress Pathway Mediating a Histone Methyl/Phospho Switch Is Required for Herpes Simplex Virus Reactivation
  Anna Fodor (group UG) DNA tumor virus oncogenes antagonize the cGAS-STING DNA-sensing pathway
22.02.2016 Justin Flatt (group UG) Broadly Neutralizing Alphavirus Antibodies Bind an Epitope on E2 and Inhibit Entry and Egress
  Emanuel Stiegeler (group AT) Lipid Membranes Facilitate Conformational Changes Required for Reovirus Cell Entry
07.03.2016 David Beauparlant (group AT) Endogenous antigen processing drives the primary CD4+ T cell response to influenza
  Ebner Hanna (group AT) A Computationally Designed Hemagglutinin Stem-Binding Protein Provides In Vivo Protection from Influenza Independent of a Host Immune Response
21.03.2016 Branislav Ivan (group AT) Single Neutralizing Monoclonal Antibodies Targeting the VP1 GH Loop of Enterovirus 71 Inhibit both Virus Attachment and Internalization during Viral Entry
  Manuela Bieri (group SH) E2F/Rb Family Proteins Mediate Interferon Induced Repression of Adenovirus Immediate Early Transcription to Promote Persistent Viral Infection
04.04.2016 Yàngüez Emilio (group SST) Hepatitis B virus X protein identifies the Smc5/6 complex as a host restriction factor
  Schanz Merle (group AT) Zika virus in the Americas: Early epidemiological and genetic findings
18.04.2016 Sechseläuten; Nachmittag frei  
02.05.2016 Lucia Reh (group AT) Wolbachia Blocks Viral Genome Replication Early in Infection without a Transcriptional Response by the Endosymbiont or Host Small RNA Pathways
16.05.2016 Whit Monday  
30.05.2016 Domingues Patricia (group BGH) Zika Virus Targets Human STAT2 to Inhibit Type I Interferon Signaling
  Liechti Thomas (group AT) Cytomegalovirus infection enhances the immune response to influenza
13.06.2016 Friedrich Nikolas (group AT) Isolation of Human Monoclonal Antibodies That Potently Neutralize Human Cytomegalovirus Infection by Targeting Different Epitopes on the gH/gL/UL128-131A Complex
  Michel Crameri (group JP) Dengue virus subverts host innate immunity by targeting adaptor protein MAVS
27.06.2016 Rodinde Hendrickx (group SH)

Dicer functions as an antiviral system against human adenoviruses via cleavage of adenovirus-encoded noncoding RNA

  Eva Müller (group SST/BGH) A Slow Maturation Process Renders Hepatitis B Virus Infectious
11.07.2016 Lukas Studer (group SH) Codon optimization of theadenoviral fiber negatively impactsstructural protein expression andviral fitness
  Lewandowska Dagmara (group AT) Dengue virus sero-cross-reactivity drives antibodydependentenhancement of infection with zika virus
25.07.2016 Summer holidays  
08.08.2016 Summer holidays  

Autumn semester 2015

DateSpeakerPaper Title
10.08.2015No Journal Club: Summer Holidays
24.08.2015No Journal Club: Summer Holidays
07.09.2015Zhaozhi Sun (group AT)Twenty-Eight Years of Poliovirus Replication in an Immunodeficient Individual: Impact on the Global Polio Eradication Initiative
Filip Golebiowksi (group BGH)Vaccines for preventing influenza in healthy adults
21.09.2015Angela Kuhn (group SH)THY-1 Cell Surface Antigen (CD90) Has an Important Role in the Initial Stage of Human Cytomegalovirus Infection
Michael Bauer (group UG)A stable trimeric influenza hemagglutinin stem as a broadly protective immunogen

Hemagglutinin-stem nanoparticles generate heterosubtypic influenza protection

05.10.2015Fiona Steiner (group JP)A Dynein Light Chain 1 Binding Motif in Rabies Virus Polymerase L Protein Plays a Role in Microtubule Reorganization and Viral Primary Transcription
Rodinde Hendrickx (group SH)Inhibition of cGAS DNA Sensing by a Herpesvirus Virion Protein
19.10.2015Caroline Lanz (group SST)Transcription Profiling Demonstrates Epigenetic Control of Non-retroviral RNA Virus-Derived Elements in the Human Genome
Vibhu Prasad (group UG)Viral Nucleases Induce an mRNA Degradation- Transcription Feedback Loop in Mammalian Cells
02.11.2015Abhilash Kannan (group UG)A non-canonical role of the p97 complex in RIG-I antiviral signaling
Martin Pacesa (group SH)Human endogenous retrovirus-K contributes to motor neuron disease
16.11.2015Antonio Lopez (group BGH)Cullin4 Is Pro-Viral during West Nile Virus Infection of Culex Mosquitoes
30.11.2015Corinna Patzina (group BGH)PQBP1 Is a Proximal Sensor of the cGAS-Dependent Innate Response to HIV-1
Umut Karakus (group SST)Defining Hsp70 Subnetworks in Dengue Virus Replication Reveals Key Vulnerability in Flavivirus Infection
14.12.2015Daria Seiler (group UG)Phosphatidylserine Vesicles Enable Efficient En Bloc Transmission of Enteroviruses
Fanny Georgi (group UG)Adenovirus Entry From the Apical Surface of Polarized Epithelia Is Facilitated by the Host Innate Immune Response
28.12.2015No Journal Club

Spring semester 2015

DateSpeakerPaper title
12.01.2015Victoria Green (group Pelkmans)Use of Host-like Peptide Motifs in Viral Proteins Is a Prevalent Strategy in Host-Virus Interactions
Emanuel Stiegeler (group AT)Escherichia coli surface display of single-chain antibody VRC01 against HIV-1 infection
26.01.2015Patricia Nigg (group JP)RNA viruses promote activation of the NLRP3 inflammasome through a RIP1-RIP3-DRP1 signaling pathway
Miguel Maurer (group LH)Enteric bacteria promote human and mouse norovirus infection of B cells
09.02.2015David Beauparlant (group AT)Reversion of advanced Ebola virus disease in nonhuman primates with ZMapp
Hanna Ebner (Group AT)Rapid development of broadly influenza neutralizing antibodies through redundant mutations
23.02.2015Branislav Ivan (group AT)Induction of broadly cross-reactive antibody responses to the influenza HA stem region following H5N1 vaccination in humans
Manuela Bieri (group SH)Sorting of small infectious virus particles by flow virometry reveals distinct infectivity profiles
09.03.2015No Journal Club
23.03.2015Dominik Müller (group JP)Structural basis for RNA replication by the hepatitis C virus polymerase
06.04.2015No Journal Club: Easter Monday
20.04.2015Emilio Yàngüez (group SST)Multi-spectral fluorescent reporter influenza viruses (Color-flu) as powerful tools for in vivo studies
Lucia Reh (group AT)Leukocyte-Derived IFN-α/β and Epithelial IFN-λ Constitute a CompartmentalizedMucosal Defense System that Restricts Enteric Virus Infections
04.05.2015Schanz Merle (group AT)Mechanism of Human Antibody-Mediated Neutralization of Marburg Virus
Liechti Thomas (group AT)Interferon-λ restricts West Nile virus neuroinvasion by tightening the blood-brain barrier
18.05.2015Pascal Roulin (group UG)IFITM proteins incorporated into HIV-1 virions impair viral fusion and spread
Vardan Andriasyan (group UG)Structural analysis of herpes simplex virus by optical super-resolution imaging
Attention! New time and new room!
Monday of every second week (alternating with HIV journal club) 4 pm at room Y21-D-68a
01.06.2015Marie-Theres Pohl (group SST)DDX60 Is Involved in RIG-I-Dependent and Independent Antiviral Responses, and Its Function Is Attenuated by Virus-Induced EGFR Activation
Friedrich Nikolas (group AT)Long-term measles-induced immunomodulation increases overall childhood infectious disease mortality
Attention! Another new room!
Monday of every second week (alternating with HIV journal club) 4 pm at room Y44-H-05
15.06.2015Dagmara Lewandowska (group AT)Comprehensive serological profiling of human populations using a synthetic human virome
Domingues Patricia (group BGH)Hepatitis C Virus RNA Functionally Sequesters miR-122
29.06.2015Artur Yakimovich (group UG)Poxvirus Decapping Enzymes Enhance Virulence by Preventing the Accumulation of dsRNA and the Induction of Innate Antiviral Responses
Michel Crameri (group JP)TRIM32 Senses and Restricts Influenza A Virus by Ubiquitination of PB1 Polymerase
13.07.2015Eva Müller (group SST)Adenovirus-mediated artificial MicroRNAs targeting matrix or nucleoprotein genes protect mice against lethal influenza virus challenge
Nicole Stichling (group UG)RNase L Activates the NLRP3 Inflammasome during Viral Infections
27.07.2015Luca Murer (group JP)Life-threatening influenza and impaired interferon amplification in human IRF7 deficiency
Hannah Turkington (group BGH)Antibodies to influenza nucleoprotein cross-react with human hypocretin receptor 2

Autumn semester 2014

DateSpeakerPaper title
08.09.2014Ion Tripa (group AT)Remission of Disseminated Cancer After Systemic Oncolytic Virotherapy
Izadora Demmer (group SH)A genetic fiber modification to achieve matrix-metalloprotease-activated infectivity of oncolytic adenovirus
22.09.2014Beatrice Vetter (group NZR)Genomic surveillance elucidates Ebola virus origin and transmission during the 2014 outbreak
Abhilash Kannan (group UG)A Neuron-Specific Host MicroRNA Targets Herpes Simplex Virus-1 ICP0 Expression and Promotes Latency
06.10.2014Caroline Lanz (group SST)The Interferon Signaling Antagonist Function of Yellow Fever Virus NS5 Protein Is Activated by Type I Interferon
Rodinde Hendrickx (group SH)Late Endosomal Trafficking of Alternative Serotype Adenovirus Vaccine Vectors Augments Antiviral Innate Immunity
20.10.2014Michel Crameri (group JP)MxB binds to the HIV-1 core and prevents the uncoating process of HIV-1
Daria Mudrak (group UG)Stem Cells Loaded With Multimechanistic Oncolytic Herpes Simplex Virus Variants for Brain Tumor Therapy
03.11.2014Matteo Bianchi (group LH)Lassa virus entry requires a trigger-induced receptor switch
Michael Bauer (group UG)The ER-Associated Protein ZDHHC1 Is a Positive Regulator of DNA Virus-Triggered, MITA/STING-Dependent Innate Immune Signaling
17.11.2014Fiona Steiner (group JP)Stem-Loop Recognition by DDX17 Facilitates miRNA Processing and Antiviral Defense
Vibhu Prasad (group UG)Lack of XBP-1 Impedes Murine Cytomegalovirus Gene Expression
01.12.2014Robert Witte (group UG)Modelling viral and immune system dynamics
Mustafa Eroglu (group AT)HIV-1 Entry in SupT1-R5, CEM-ss, and Primary CD4+ T Cells Occurs at the Plasma Membrane and Does Not Require Endocytosis
15.12.2014Jürg Cabalzar (group JP)Cytomegalovirus-mediated activation of pyrimidine biosynthesis drives UDP-sugar synthesis to support viral protein glycosylation
29.12.2014No Journal Club

Spring semester 2014

DateSpeakerPaper title
10.02.2014Ebner Hanna (group AT)Broadly neutralizing hemagglutinin stalk-specific antibodies require FcγR interactions for protection against influenza virus in vivo
24.02.2014David Beauparlant (group AT)Pan-viral specificity of IFN-induced genes reveals new roles for cGAS in innate immunity
Nigg Patricia (group JP)The Consequences of Reconfiguring the Ambisense S Genome Segment of Rift Valley Fever Virus on Viral Replication in Mammalian and Mosquito Cells and for Genome Packaging
10.03.2014Lucia Reh (group AT)Novel restriction factor RNA-associated early-stage anti-viral factor (REAF) inhibits human and simian immunodeficiency viruses
I-Hsuan Wang (group UG)Epstein-Barr Viral Productive Amplification Reprograms Nuclear Architecture, DNA Replication, and Histone Deposition
24.03.2014Edinger Thomas (group SST)UVRAG is required for virus entry through combinatorial interaction with the class C-Vps complex and SNAREs
07.04.2014Schanz Merle (group AT)Specific and Nonhepatotoxic Degradation of Nuclear Hepatitis B Virus cccDNA
Pascal Roulin (group UG)Protection against filovirus diseases by a novel broad-spectrum nucleoside analogue BCX4430
21.04.2014NO Journal Club: Easter Monday
05.05.2014Müller Dominik (group JP)Functional Evidence for the Involvement of Microtubules and Dynein Motor Complexes in TRIM5α-Mediated Restriction of Retroviruses
Liechti Thomas (group AT)Essential role for autophagy in the maintenance of immunological memory against influenza infection
19.05.2014Manuela Bieri (group SH)Differential innate immune response programs in neuronal subtypes determine susceptibility to infection in the brain by positive-stranded RNA viruses
Yàngüez Emilio (group SST)Cellular DDX21 RNA Helicase Inhibits Influenza A Virus Replication but Is Counteracted by the Viral NS1 Protein
02.06.2014 Branislav Ivan (group AT)Single-Cell Analysis Uncovers Extensive Biological Noise in Poliovirus Replication
Pohl Marie-Theres (group SST)Influenza A(H7N9) virus gains neuraminidase inhibitor resistance without loss of in vivo virulence or transmissibility
16.06.2014Lewandowska Dagmara (group AT)Host Species Restriction of Middle East Respiratory Syndrome Coronavirus through its Receptor Dipeptidyl Peptidase 4
Artur Yakimovich (group UG)siRNA Screen of Early Poxvirus Genes Identifies the AAA+ ATPase D5 as the Virus Genome-Uncoating Factor
30.06.2014Friedrich Nikolas (group AT)Hepatitis C virus cell-cell transmission and resistance to direct-acting antiviral agents
Vardan Andriasyan (group UG)Emergence and Transmission of Arbovirus Evolutionary Intermediates with Epidemic Potential
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28.07.2014Stefania Luisoni (group UG)The Nogo Receptor NgR1 Mediates Infection by Mammalian Reovirus
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11.08.2014Summer holidays
25.08.2014Summer holidays